JOB DESCRIPTION

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We are looking for a Senior Research Technician to take ownership of a high-impact project on non-genetic drug resistance in melanoma—and we want someone who treats this as their own scientific mission. Your core task: develop and implement a physiologically relevant 3D model that captures the real-time crosstalk between tumor cells and the microenvironment, directly informing combination strategies to overcome treatment failure. We need a hands-on expert in primary cell culture, multiplex assays, and 3D scaffolds someone who troubleshoots independently, mentors effectively, and bridges lab work with translational goals.

MAIN RESPONSIBILITIES

- Establish and optimize a 3D co-culture model integrating melanoma cells with stromal/immune components to mimic the tumor microenvironment.
- Perform drug sensitivity assays and longitudinal viability tests to monitor treatment response and acquired resistance.
- Conduct molecular analyses (RNA/protein extraction, qPCR, Western blotting, cytokine profiling) to characterize non-genetic adaptive changes.
- Carry out high-content imaging and quantitative microscopy to assess spatial interactions, invasion, and phenotypic plasticity within 3D constructs.
- Maintain detailed electronic lab records, analyze data with statistical rigor, and present results in team meetings.
- Train and supervise junior technicians/students, manage reagent inventory, and troubleshoot protocols proactively.
- Collaborate with bioinformaticians to integrate wet-lab data with omics datasets, feeding results into therapeutic strategy development.

QUALIFICATIONS AND EXPERIENCIE





- Master in Biomedicine or closely related field, with a focus on cancer research.
- Experience in tissue culture and data analysis
- Strong experience in molecular and cellular biology techniques (DNA and RNA isolation, RNA quantification, qPCR and immunofluoresence).
- Strong experience in cell culture, including the establishment of primary cultures.
- Experience in proteomics, particularly in O-Link analysis.
- Hands-on experience in clinical research environments.
- Basic knowledge of Rstudio.
- Good command of English, both written and spoken.
- International experience will be considered an asset.
- Experience in sòlid tumors tumors will be considered an asset.
- Proactive, motivated, and responsible individual with strong organizational skills and the ability to work autonomously

WHAT WE OFFER

- Indefinite contract (Science Law 14/2011) Full-time contract
- 2 gross salary
- Incorporation date: 1st of September
- Gross annual remuneration inherent to the square objected to this call, will be fixed based on the experience provided and the skills of the candidate, distributed in 12 payments.
- Versátil payment (childminding vouchers and meal voucher).
- 23 days holiday and 5 days for personal matters.
- Training capsules by the company.
- Be part of an excellent multidisciplinary research centre with the HRS4R badge.
- Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. xcgbitx The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

FOR MORE INFORMATION

FOR APPLICATIONS

The call for applications will close on August 10th, 2026.

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📌 2026_112_SENIOR RESEARCH TECHNICIAN (Malla)
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