Barcelona - Spain (3 days working from the office and 2 days working from home). BioPharmaceuticals Medical (BPM) strives for the best patient outcomes by providing healthcare decision-makers around the world with the evidence and confidence they need on AstraZeneca therapies, as well as supporting our internal stakeholders with medical insights and expertise. The Director, Clinical Programming is a senior subject matter expert and functional leader within RWS&A; RWD Office Clinical Programming.

The role is accountable for shaping and delivering high-quality, efficient, and fit-for-purpose clinical programming that supports the Statistics group and broader evidence generation portfolio. The incumbent provides strategic and technical leadership across both outsourced and in-house programming activities, independently makes decisions on programming approaches, standards, quality, and risk, and orchestrates delivery across internal teams and vendor partners.

Typical

AccountabilitiesSets the direction for Clinical Programming within the RWS&A; RWD Office and helps shape the function's operating model, priorities, standards, capabilities, and longer-term development.Acts as the senior Clinical Programming subject matter expert and primary point of escalation for complex, novel or high-impact programming questions.Provides end-to-end oversight and orchestration of programming activities delivered by external partners, including planning, technical direction, quality expectations, issue resolution, and accountability for timely delivery.Leads and, where appropriate, performs in-house programming activities in support of the Statistics group, including delivery of analysis datasets, tables, listings, figures, validation, and other fit-for-purpose deliverables.Uses and advocates for approved AI-enabled tools, where appropriate,



to improve efficiency and quality while ensuring validation, traceability, human oversight, and compliance with applicable policies.Establishes fit-for-purpose governance and quality controls across internal and outsourced programming, and drives timely resolution of delivery, quality, compliance and capacity risks.Builds strong partnerships with Statistics, Data Management, Data Science, Epidemiology, Evidence Delivery and other stakeholders to translate study and analysis needs into executable programming plans.Develops and implements programming standards, reusable solutions, templates, automation, and best practices that improve consistency, quality, scalability and cycle times across the portfolio.Influences senior internal and external stakeholders through clear technical recommendations, evidence-based decisions and pragmatic solutions.Provides technical leadership, coaching and mentorship to junior programmers and contributes to capability building, knowledge sharing, recruitment and onboarding.Extensive industry experience in clinical or statistical programming, including demonstrated leadership of complex programming deliverables and projects.Advanced SAS programming skills with a high degree of proficiency in SAS macros.Deep knowledge of clinical and real-world evidence generation, the clinical development process, analysis data flows and programming deliverables.Strong knowledge of applicable programming, data and reporting standards,



with the ability to define and implement fit-for-purpose standards.Experience leading AI, automation or digital workstreams and translating emerging technology into controlled, practical business use.Demonstrated experience overseeing programming delivered by CROs or other external partners and holding partners accountable for quality, timelines and issue resolution.Demonstrated ability to lead and deliver in-house programming activities, including planning, technical review, validation and documentation.Experience leading cross-functional initiatives and influencing senior stakeholders without relying on direct authority.Strong understanding of quality, traceability, reproducibility, audit readiness and regulatory expectations relevant to programming.Strong communication, collaboration, planning, prioritization and vendor?Strong working knowledge of at least one additional relevant language or technology, such as R, Python, SQL or XML.Relevant professional certification such as SAS certification.Key Relationships to reach solutionsInternal (to AZ or team)Leadership and all levels across BPM Evidence/RWS&ARWS;&A; RWD Office and BPM Evidence StatisticsData Management, Data Science, Epidemiology and Evidence Delivery partnersStudy and project functional leadsAI, automation, technology, quality and standards workstreamsClinical Programming colleagues and broader programming communitiesExternal (to AZ)CRO and vendor programming leads, project managers and technical teamsTechnology and service providers supporting programming, automation or AI initiativesOther external partners and collaborators, as required.We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

📌 Director Of Ai-Driven Clinical Programming (Barcelona)
🏢 Astra Zeneca
📍 Barcelona