Principal Scientist, Biophysics/Biochemical DMTL Automation At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. We are seeking an innovative, highly collaborative, and self-directed Principal Scientist to advance next-generation biophysical and biochemical capabilities supporting Design-Make-Test-Learn (DMTL) workflows across Discovery within Discovery Technologies and Molecular Pharmacology (DTMP).

Based in Toledo, Spain, this role will generate and interpret high-quality Surface Plasmon Resonance (SPR) and biochemical data to guide decisions from hit identification through lead optimization. The successful candidate will develop innovative assays, implement automated workflows, and partner across chemistry, biology, computational sciences, automation, and platform teams to accelerate DMTA cycles and strengthen the speed, quality, and predictability of discovery. Generate and interpret kinetic, affinity, thermodynamic, and biochemistry data to guide SAR and critical project decisions DMTA Acceleration & Data Generation + Deliver high-quality biophysical and biochemistry data that accelerates DMTL cycles and enables rapid, data-driven discovery decisions + Act as an independent scientist, identifying opportunities, solving complex technical challenges, and leading cross-functional Discovery project teams to shape biophysical and biochemical strategies that advance project objectives + Collaborate across chemistry, biology, computational sciences,



structural biology, automation, and data science within General Discovery Chemistry (GDC) and DTMP to translate biophysical and biochemical insights into portfolio decisions Education - Demonstrated ability to determine robust binding affinities and kinetic parameters, supported by appropriate experimental controls, replicates, error analysis, and scientific interpretation - Demonstrated expertise in assay development, optimization, troubleshooting, data analysis, and curve fitting, beyond execution of established protocols - Strong scientific communication and collaborative problem-solving skills, including the ability to present and defend data to multidisciplinary project teams Experience supporting Design-Make-Test-Learn (DMTL) workflows - Experience working in multidisciplinary teams spanning chemistry, biology, automation, and data sciences Critical thinking with the ability to translate complex data into clear, actionable scientific insights - Big Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability **In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees' and companies' performance of the previous calendar year, or sales commissions.

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