At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at .Job Function: Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function: Biological ResearchJob Category: Scientific/TechnologyAll Job Posting Locations: Toledo, SpainJob Description: Principal Scientist, Biophysics/Biochemical DMTL AutomationLocation: Toledo, SpainLevel: Principal Scientist (ST7)Role Overview:We are seeking an innovative, highly collaborative, and self-directed Principal Scientist to advance next-generation biophysical and biochemical capabilities supporting Design-Make-Test-Learn (DMTL) workflows across Discovery within Discovery Technologies and Molecular Pharmacology (DTMP). Based in Toledo, Spain, this role will generate and interpret high-quality Surface Plasmon Resonance (SPR) and biochemical data to guide decisions from hit identification through lead optimization. The successful candidate will develop innovative assays, implement automated workflows, and partner across chemistry, biology, computational sciences, automation, and platform teams to accelerate DMTA cycles and strengthen the speed, quality, and predictability of discovery.Key Responsibilities: Biophysical and Biochemical Assay Development & Discovery SupportDesign, develop, and execute SPR and biochemical assays to support hit validation and lead optimization across discovery programsGenerate and interpret kinetic, affinity, thermodynamic, and biochemistry data to guide SAR and critical project decisions DMTA Acceleration & Data GenerationDeliver high-quality biophysical and biochemistry data that accelerates DMTL cycles and enables rapid, data-driven discovery decisionsDevelop robust and scalable experimental workflows that expand throughput and reproducibility across the portfolio Technology Innovation & AutomationDrive the development and implementation of automated biophysical and biochemical lab design and workflows that increase experimental scale, consistency,



and scientific impactPartner with automation, informatics, engineering, and platform teams across teams to integrate biophysical and biochemical capabilities into scalable DMTA workflows and next‑generation discovery platforms Scientific Collaboration & Technical LeadershipAct as an independent scientist, identifying opportunities, solving complex technical challenges, and leading cross‑functional Discovery project teams to shape biophysical and biochemical strategies that advance project objectivesCollaborate across chemistry, biology, computational sciences, structural biology, automation, and data science within Global Discovery Chemistry (GDC) and DTMP to translate biophysical and biochemical insights into portfolio decisions Qualifications EducationPh. D. in Biophysics, Biochemistry, Structural Biology, or a related scientific disciplineRequired Experience & Skills 8+ years of experience developing and executing biophysical and biochemical assays in a pharmaceutical, biotechnology, or academic research environmentDemonstrated hands‑on expertise with SPR, complementary biophysical platforms, and biochemical techniquesDemonstrated ability to determine robust binding affinities and kinetic parameters, supported by appropriate experimental controls, replicates, error analysis, and scientific interpretationExperience with assay automation, high‑throughput experimentation, or laboratory roboticsStrong understanding of protein‑ligand interactions, kinetics, thermodynamics, and molecular mechanismsDemonstrated expertise in assay development, optimization, troubleshooting, data analysis, and curve fitting, beyond execution of established protocolsAbility to interpret complex biophysical and biochemical datasets and translate results into actionable drug discovery decisionsStrong scientific communication and collaborative problem‑solving skills,



including the ability to present and defend data to multidisciplinary project teams Preferred Experience Experience supporting Design‑Make‑Test‑Learn (DMTL) workflowsFamiliarity with computational chemistry, structural biology, or AI‑enabled drug discovery approachesExperience working in multidisciplinary teams spanning chemistry, biology, automation, and data sciences Non‑Technical Skills Scientific curiosity, innovation mindset, and strong experimental judgmentCritical thinking with the ability to translate complex data into clear, actionable scientific insightsCollaborative, self‑directed, and effective in fast‑paced, highly matrixed environments Required Skills: Preferred Skills: Big Data ManagementCritical ThinkingData ReportingData SavvyDrug Discovery DevelopmentMolecular DiagnosticsOrganizingPharmaceutical MicrobiologyProblem SolvingProduct KnowledgeProject ReportingProject ScheduleResearch ProposalsScientific ResearchStandard Operating Procedure (SOP)Standard Scientific Processes and ProceduresStrategic ThinkingSustainability The anticipated base pay range for this position is: €63 700,00 - €109 480,00Benefits: an annual bonus with set target (% of pay) depending on pay grade / location, where the vigente amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions.Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well‑being reimbursement, programs for financial, physical and mental health.We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans.*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change. Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive. Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities. If you need support at any stage of the recruitment process, please complete our candidate accommodation request form so we can assist you.Do Not Sell or Share My Personal Information Limit the Use of My Personal Information#J-18808-Ljbffr

📌 Principal Scientist, Biophysics/Biochemical Dmtl Automation (Toledo)
🏢 Johnson & Johnson
📍 Toledo