You are here:Home > Junior Bioinformatician – Computational Protein Design and Software InfrastructureJunior Bioinformatician – Computational Protein Design and Software InfrastructureThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a adaptable and efficient administration and by high-end and innovative technologies.

We are looking for a highly motivated junior bioinformatician to support the computational protein design work of the Design of Biological Systems group (Dr. Luis Serrano) and its software infrastructure. This is a technical support role rather than a research training position: the bioinformatician will work on concrete group needs, in close collaboration with researchers, PhD students and experimental collaborators.

Main responsibilities:

Validation of a diffusion model for peptide generation:

run benchmarks, compare generated peptides using structural and energetic criteria (FoldX, AlphaFold3, Boltz) and report results to the team.

Automation of molecule parameterisation in FoldX:

develop and maintain scripts and pipelines that generate FoldX parameters for new small molecules and non-standard residues.

Software maintenance and distribution:

take charge of compiling, maintaining and version-controlling the group’s development and distribution infrastructure,



including FoldX (multiplatform builds, dependency updates, portable binaries and release support).

About the teamOur group aims to quantitatively understand biological systems and to rationally design and modify their behaviour. We develop software that spans biological databases to structural modelling at the atomic level, including the FoldX suite (foldxsuite.crg.es) and ModelX (modelx.crg.es). We combine these computational tools with experiments to validate our predictions.

Whom would we like to hire?Professional experienceMust Have

You have a basic understanding of protein structure and structural biology

You have working knowledge of Python and of the Linux command line

Desirable but not required/ Nice to have

C++ programming, or willingness to learn it on the job

Version control (Git) and build tools (CMake, Make, compilers on Linux and macOS)

Experience with HPC clusters and job schedulers

Experience with structural modelling tools (FoldX, AlphaFold, Boltz, Rosetta or similar)

Experience running or evaluating machine-learning models

SQL databases

Education and training

You hold a bachelor’s or master’s degree in bioinformatics, Biotechnology,



Biochemistry, Chemistry, Computer Science or a related field

Languages

You are fluent in English, spoken and written

Technical skills

You can write and maintain scripts that automate computational workflows

Competences

Highly developed organisational skills

Reliability and attention to detail

Ability to document your work clearly

Team player in an interdisciplinary environment

The Offer – Working Conditions

Contract duration:

Technical and scientific activities contract linked to the project (with an estimated duration of 1 year).

Estimated annual gross salary:

Salary is commensurate with qualifications and consistent with our pay scales.

Target start date:

January 2026.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .

We offer and

promote a diverse and inclusive environment

and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The

CRG is committed to reconcile a work and family life

of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Funded by the European Union (ERC, SafeDelivery, Grant Agreement Nº 101266773)”

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📌 Junior Bioinformatician – Computational Protein Design and Software Infrastructure (Madrid)
🏢 Crg
📍 Madrid