This is an in-office role based in Barcelona, ES, with a requirement to work a minimum of three days per week on-site . Remote or travel flexibility is not available.

About AstraZeneca and AISI

At AstraZeneca, technology and science meet to change what is possible for patients. We are building a connected, end-to-endEnterprise AI engine that unites data foundations, AI technology, process reinvention, and business-facing AI to accelerate results across the whole value chain. Success depends on being an exceptional connector: you will leverage existing capabilities, promote reuse, share breakthrough ideas across geographies and functions, and focus on scaling impact rather than building in isolation.

AI Science & Innovation (AISI)sits at the center of AstraZeneca's R&D; AI transformation. Our remit is to build, buy, and deliver the AI models and agents that change pipeline outcomes, across discovery, translational science, biomarkers, and clinical development.

Within AISI, theBioPharma Clinical Development AI teamis building world-class AI capability to accelerate the design, conduct, and analysis of clinical trials across our BioPharmaceuticals pipeline, in both early and late phase programmes. We partner closely with clinical development, regulatory, and biometrics teams to bring better treatments to patients faster, while adhering to the highest evidentiary standards.

The Opportunity

Clinical development is one of the most data-rich and decision-intensive parts of bringing a new medicine to patients. Trial design, patient selection, dose optimisation, biomarker strategy, and safety evaluation are all areas where AI and machine learning can add rigour, speed, and precision, as a powerful complement to clinical and statistical expertise.





You will work in cross-functional teams across the key BioPharmaceuticals disease areas of cardiovascular, renal, metabolic disease, respiratory, and immunology. Alongside experienced data scientists and clinical collaborators, you will apply modern AI methods to measurably advance the drug pipeline and help build reusable approaches that scale across programmes.

Foundation models, agentic systems, and causal AIare advancing rapidly, and the regulatory and methodological frameworks around them are evolving in parallel. In this role you will be hands-on at the frontier, developing, evaluating, and deploying AI methods that directly inform clinical trial design and decision-making. Every model you contribute to will eventually touch a trial that decides whether a patient gets a better therapy. That is the bar we hold ourselves to.

What You Will Do

- Develop and deploy AI/ML methodsfor clinical trials, including trial design support, dose optimisation, biomarker discovery, digital twins, predictive modelling, and safety and efficacy signal detection.
- Contribute to end-to-end project delivery, from problem framing and methodology selection through to validation and adoption within study teams, with guidance from senior colleagues on more complex initiatives.
- Partner with Clinical Development, Biometrics,



and Regulatory colleaguesto embed AI approaches into study design and decision-making.
- Build reusable, well-documented data productssuch as pipelines, packages, and applications, with a software engineering mindset.
- Apply modern methodologiesincluding foundation models, agentic AI, generative patient models, longitudinal modelling, Bayesian inference, and causal inference, with clear evaluation criteria.
- Practise data-centric AIand contribute to evaluation and benchmarking frameworks suitable for clinical and regulatory settings.
- Engage with internal and external scientific communities, contributing to publications and conference presentations.

What You Will Bring

- A degree in a quantitative discipline(e.g. Computer Science, Machine Learning, Statistics, Mathematics, Biomedical Informatics, Computational Biology, Physics, Engineering) at Master's, or PhD level, or equivalent experience.
- Demonstrated experiencein AI/ML method development, shown through delivered models, publications, open-source contributions, or applied projects, ideally in clinical, biomedical, or drug development settings.
- Hands-on experience with biological or clinical data, such as molecular (DNA, RNA, protein), imaging, or clinical text (EHR, clinical notes).
- Technical capability in one or more modern AI areas, such as foundation model training and fine-tuning, Bayesian inference, temporal and longitudinal modelling, multimodal integration, model interpretability, or post-training and alignment.
- Strong Python skills, experience with PyTorch and modern LLM tooling, and familiarity with cloud platforms (e.g. AWS, Azure, GCP).
- Excellent communication skills, with the ability to translate comp

📌 Senior Scientist (Barcelona)
🏢 AstraZeneca
📍 Barcelona