Organisation/Company Universitat de Barcelona Department Organisation profile Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Positions PhD Positions Application Deadline 3 Nov ***:59 (Europe/Madrid) Country Spain Type of Contract Temporary Job Status Full-time Hours Per Week 37,5 Offer Starting Date 15 Jan ** Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
T
RCAT: Transcription–Replication Conflicts as Anti-cancer Targets
Transcription–replication conflicts (TRCs) are a major source of DNA replication stress and DNA damage. Growing evidence suggests that TRCs contribute to genome instability in many cancers, creating selective pressure for tumor cells to adapt and tolerate these conflicts. Despite this, their therapeutic potential remains largely unexplored. TRCAT will investigate the molecular vulnerabilities created by TRCs and evaluate whether targeting these conflicts and their associated genetic dependencies can open new therapeutic opportunities for cancer.
THE PROJECT
Identify genetic interactions driving genome instability at transcription-replication conflicts.
Perform combinatorial functional CRISPR screenings.
Conduct drug assays targeting TRC-associated dependencies.
Evaluate therapeutic potential through preclinical assays (scratch/wound-healing assays, spheroids, and related models
ABOUT THE GROUP
We are a multidisciplinary group dedicated to understanding and therapeutically exploiting genome instability in cancer, with a particular focus on transcription-addicted tumors such as Ewing sarcoma. Our work integrates wet-lab molecular biology in vitro studies with human cell lines,



in vivo Drosophila models, and computational genomics to dissect how oncogenic transcriptional programs generate genome instability and how this vulnerability can be turned into a therapeutic opportunity.
CANDIDATE PROFILE
PhD in Genetics, Biomedicine, Molecular/Cell Biology, or a related field
Strong wet-lab experience in genome stability research, including DNA damage, DNA replication stress, and/or genome instability assays
Strong background in the molecular biology and pathogenesis of Ewing sarcoma
Experience in mammalian cell culture and molecular/cellular biology techniques (e.g., immunofluorescence, Western blot, qPCR, ChIP,...)
Experience with CRISPR screens and/or functional genomics
Experience with genome-wide assays and analysis, including NGS and bioinformatics
Certificate in animal experimentation (A+B+C)
Demonstrated ability to independently design experiments, troubleshoot, and develop research projects
Ability to analyze, interpret, and integrate complex experimental and genomic datasets
Strong publication record, including at least two first-author publications
Excellent scientific communication and writing skills
Strong wet-lab experience in genome stability research, including DNA damage, DNA replication stress, and/or genome instability assays
Experience in mammalian cell culture and molecular/cellular biology techniques (e.g.,



immunofluorescence, Western blot, qPCR, ChIP,...)
Experience with CRISPR screens and/or functional genomics
Experience with genome-wide assays and analysis, including NGS and bioinformatics
Demonstrated ability to independently design experiments, troubleshoot, and develop research projects
Ability to analyze, interpret, and integrate complex experimental and genomic datasets
Strong publication record, including at least two first-author publications
Excellent scientific communication and writing skills
Fluency in English
Specific Requirements
PhD in Genetics, Biomedicine, Molecular/Cell Biology, or a related field
Strong background in the molecular biology and pathogenesis of Ewing sarcoma
Certificate in animal experimentation (A+B+C)
Languages ENGLISH Level Excellent
Research Field Biological sciences
Additional Information
A multidisciplinary, collaborative research environment with a strong publication record and active national/international collaborations
Access to leading core facilities (imaging, genomics, proteomics)
Training and career development support, including support for national/international fellowship applications
An international lab based in Barcelona
Eligibility criteria
A specific committee will evaluate the applications using the following criteria:
Suitability of the CV for the job (maximum 20)
PhD in the specific research field (maximum 20)
Motivation letter (maximum 20)
Experience in the research field (maximum 20). E.g.: >3 years (15 points), <3 years (5 points)
Other criteria based on specific merits (maximum 20)
Selection process
The specific committee will agree upon an a

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