Overview
The Höpfler lab at the Institute for Genomic Regulation (CRG) is offering a postdoctoral position focused on RNA biology and gene regulation. The role involves leading a project to develop sequencing methods that identify messenger RNA (mRNA) decay substrates and to decipher the mechanisms of degradation.
Responsibilities

Develop sequencing approaches to identify peptide-mediated mRNA decay (PMD) substrates
Perform bioinformatic data analysis and visualization of sequencing datasets
Identify and mechanistically characterize PMD candidate substrates
Present data at international conferences and prepare manuscripts
Lead and manage international collaborations
Actively participate in lab meetings and contribute to a culture of technical excellence and scientific curiosity

Qualifications
We are particularly interested in candidates with a hybrid wet‑lab and bioinformatics background who have a track record in RNA biology or gene regulation.
Must Have

Bioinformatics experience in the analysis of (RNA) sequencing data




Experience with common laboratory techniques in cell and molecular biology
PhD degree (or expected to complete the degree before starting) in cell/molecular biology, bioinformatics, or a related field
Strong publication record commensurate with career stage
Ability to pursue research projects independently

Desirable

Experience with massively parallel reporter assays (MPRAs)
Experience exploring mRNA turnover on a transcriptome‑wide scale
Background in RNA biology, translational control, or related areas

Languages

Fluency in written and spoken English

Computer Skills

Proficiency with data analysis software (R, Python)
Experience using high‑performance computing clusters
Advanced MS Office experience

Competences

Curiosity and critical thinking
Rigor, organization, and autonomy
Strong analytical, interpersonal, and communication skills

Offer – Working Conditions

Contract duration: Technical and scientific activities contract (estimated dur

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