Organisation/Company Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) Department Vice-Rectorate for Research Research Field Neurosciences » Other Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 5 Nov 2026 - 23:59 (Europe/Madrid) Country Spain Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Other EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Neuronal hyperactivity, myelin defects and impaired oligodendrocyte maturation occur early in Alzheimer´s disease. In the healthy brain, neuronal activity regulates myelination, and microglia help control both neuronal excitability and myelin maintenance. How these processes interact in early AD is still unknown. We hypothesize that early neuronal hyperactivity in AD, through microglia,



drives aberrant myelination that contributes to network instability and cognitive decline. To test this, we will use 3xTg-AD mice to study whether hyperexcitability in hippocampal CA1 alters microglia, oligodendrogenesis and myelin, and whether these changes drive early anxiety- and fear-related behaviors through hippocampal-prefrontal-amygdala circuits. Finally, we will test whether targeting hyperactivity-dependent myelination can prevent these alterations, as a potential therapeutic strategy. This project will clarify how early circuit dysfunction leads to white matter damage and may identify new therapeutic targets for the earliest stages of AD. Master's degree in Biology, Biochemistry, Biomedicine or related fields, Additional Information Additional comments Please read carefully sections 4 and 7 of the call. #J-18808-Ljbffr

📌 Neuronal Hyperactivity and Maladaptive Myelination in Early Alzheimer’s Disease Circuit Dysfunction (Canarias)
🏢 Universidad del Pais Vasco/Euskal Herriko Unibertsitatea (UPV/EHU)
📍 Canarias