Introduction to the vacant position:
The Enzyme Sensors and Chemical Probes group is looking for a motivated Ph.D. student to dissect post-translational modifications (PTMs) across the microtubule network of the cell, by developing new inhibitors and fluorescent sensors of metalloenzymes. This positions fit within the scope of the project CHEMTUBIO (ERC Starting Grant), and within our overall aim of revealing disease mechanisms through the development of imaging tools and chemical probes, leading up to methods for translatable drug discovery.
Main tasks and responsibilities:
Synthetic organic chemistry: develop small molecule- and peptide-based inhibitors of metalloenzymes using in-solution and solid-phase chemistry
Enzyme assay development: investigate enzyme activity in vitro using purified recombinant proteins
Live cell imaging: study the spatiotemporal regulation of microtubule PTMs through selective enzyme inhibition and activity sensing in cell culture
Training activities:attend scientific seminars, as well as courses in scientific and transversal skills,



as part of the doctoral training
Outreach: disseminate research findings at international conferences and through publications
Requirements for candidates:
Essential:
Education: M.Sc. degree in Medicinal Chemistry, Chemical Biology, Biochemistry, or a related field
Technical expertise: demonstrated expertise in organic chemistry and/or biochemistry techniques
Transversal skills: scientific communication in English, ability to work in a diverse and interdisciplinary environment, time management, collaboration
Motivation: strong interest in cutting‑edge research and in the development of analytical skills and scientific independence
Advantageous:
Experience in solid-phase peptide synthesis
Experience in compound library synthesis
Experience with in vitro enzyme assays
Experience working within international teams or institutions
Competencies and Skills:
We value not only technical expertise but also the demonst

📌 Ph.D. student in Medicinal Chemistry (Barcelona)
🏢 BIST People Working Group
📍 Barcelona