Offer Description

Project description:

The area of Biomechanics & Mechanobiology (SIMBIOSys-BMMB) of the research unit BCN MedTech, at the Department of Communication and Information Technologies (DTIC) of the University Pompeu Fabra (UPF) offers a one-year research support position, in the context of the European Research Council Consolidator Grant (ERC CoG) O-Health (101044828). The successful candidate will continue the development of an existing systems biology model of articular cartilage regulation in healthy and osteoarthritic knee joints. The spatial mapping of cell-cell communications will be targeted, considering the cascade of events and feedback loops between synovitis and articular cartilage damage over time, and the model will be fed with patient -omics data.

Tasks to be performed:

- Validate, with experimental cell culture data, a coupled systems biology - finite element multiscale model that simulates the collective regulation of articular cartilage chondrocyte regulation, at the tissue level (RP1)
- Extensive review of the biological literature and databases, to strengthen the validation of chondrocytes mechano-sensitive regulatory network models through falsification tests (RP1)
- Generate a web-friendly simulator of the validated regulatory model, by using SBML standard (RP2)
- Exploit the multiscale model to interpret the impact of synovitis on the articular cartilage, in the lights of clinical data, by integrating proteomics measurements of patient's synovial fluids (RP3)

Group and complement: Group 3 + Level u

Dedication and working hours: Part time (30 h/week)

Planned remuneration approx: 25691.12 € / gross per year

Financing fund: ERC Consolidator Grant O-Health (ERC-2021-COG-101044828)

Where to apply Website

Requirements





Research Field Technology » Biotechnology Education Level Undergraduate

Additional Information

Eligibility criteria

Selection criteria: The selection of the candidates will be made through evaluation of the curriculum and, where appropriate, with the carrying out a test and/or interview. Valuation will be as follows:

1- Formació Acadèmica/ Academic Training (0-25 punts/ points).

- Bachelor in Biomedical Engineering

2- Altra formació i experiència professional, adequació al perfil proposat/ Other professional training and experience, adequacy to the proposed profile (0-50. punts/ points):
- At least two years of contrastable experience in multiscale and systems biology modelling applied to human joint systems

3- Altres mèrits/ Other merits (0-25 punts/ points):
- Good capacity to disseminate science in English, contrasted though previous scientific publications and participation in scientific congress, and during a possible interview
- Proficient Spanish and/or Catalan, for fluid communication with the clinical collaborators of the project, contrasted during a possible interview

The minimum score to pass the selection process is 75 points. The candidate with the highest score in the selection process will be offered the job.

Additional comments

For more information about the call, how to apply, the list of those admitted and excluded, as well as the hiring proposal, check the website:

Work Location(s)

Number of offers available 1 Company/Institute Universitat Pompeu Fabra - Engineering Country Spain City Barcelona Postal Code 08018 Street Roc Boronat 138 Geofield

Contact City

Barcelona Website

Street

Roc Boronat 138 Postal Code

08018 E-Mail

[email protected]

STATUS: EXPIRED

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