Offer Description

We offer a fully funded 48-month PhD position. The PhD student will focus on the control of bioorthogonal reactions by mechanical bond (rotaxanes). The work will imply the synthesis of interlocked molecules (and their non-interlocked analogues), which are able to undergo a biorthogonal reaction on the axle of the rotaxane. Once synthesized and characterized, the kinetics of the biorthogonal reaction will be tested, and the effect of the macrocycle around the axle will be evaluated. Rotaxanes able to respond to specific biological environments will then be employed to test the control of the bioorthogonal reactions in cells. Controlled drug release or sensing will be some of the final aims.

Selected references:

“Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation”

Angew. Chem. Int. Ed. 2025, 64, e202514796, DOI: 10.1002/anie.202514796

“Kinetic Control of Complexity in Multiple Dynamic Libraries”

Angew. Chem. Int. Ed. 2024, 63, e202406654, DOI: 10.1002/anie.202406654

“A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum”

Angew. Chem. Int. Ed. 2022, 61, e202205403, DOI: 10.1002/anie.202205403

“Dynamic Nucleophilic Aromatic Substitution of Tetrazines”

Angew. Chem. Int. Ed. 2021, 60, 18783, DOI: 10.1002/anie.202106230

Where to apply E-mail

[email protected]

Requirements

Research Field Chemistry » Organic chemistry Education Level Master Degree or equivalent

Skills/Qualifications

We seek candidates who are in possession of an MSc in Chemistry or a closely related discipline.





Specific Requirements

Experience in supramolecular chemistry, bioorthogonal chemistry and/or biomedicinal chemistry will be highly considered. Good knowledge of English is required.

Languages ENGLISH Level Excellent

Research Field Chemistry » Organic chemistry

Additional Information

Benefits

Net salary (after taxes): 1825€/month. Additionally, there is an associated funding to cover short stays or any administrative costs.

Eligibility criteria

Candidates must hold an MSc in Chemistry or a closely related discipline, obtained under educational systems belonging to the European Higher Education Area (EHEA)

Selection process

The position will be opened until October 31th or until a selected candidate is found. Tentative starting date is February 2027 (versátil). Interested applicants should submit their CV (containing at least 2 contacts for references), academic transcripts and a motivation letter directly to with subject line "PhD position 2026”.

Additional comments

El contrato es parte de la ayuda PID2025-168970NB-I00, financiado por MICIU/AEI/10.13039/501100011033 y por el FSE+

Work Location(s)

Number of offers available 1 Company/Institute IPNA-CSIC Country Spain State/Province Canary Islands City La Laguna Postal Code 38206 Street Avda. Astrofísico Francisco Sánchez 3 Geofield

Contact State/Province

Santa Cruz de Tenerife City

La Laguna Website

Street

Avda. Astrofísico Francisco Sánchez 3 Postal Code

38206

STATUS: EXPIRED

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📌 1 PhD Position available in bioorthogonal & supramolecular chemistry (España)
🏢 Sin nombre
📍 España