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Senior Research Technician – Deep Mutational Scanning of Membrane Proteins
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a adaptable and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the ' HR Excellence in Research ' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers ( Charter and Code ).




We are looking to hire a Senior Research Technician join a large-scale project performing deep mutational scanning of membrane proteins. The role involves variant library design, library generation, selections in human cell lines, DNA sequencing library generation and data analysis.
About the lab
The focus of Lehner lab is using massively parallel selection experiments to tackle the fundamental encoding problems of molecular biology. Towards this goal we have developed, benchmarked, and applied at scale experimental methods that use DNA synthesis-selection-sequencing to perform biophysical measurements including quantifying how changes in sequence alter protein stability, binding affinity, aggregation, allostery and expression. We have used these methods to produce the first comprehensive maps of long-range allsoteric communication in proteins, to quantify the effects of >500,000 variants in >500 human proteins, and to probe the genetic architecture of proteins, protein interactio

📌 Senior Research Technician (Barcelona)
🏢 Centre For Genomic Regulation
📍 Barcelona