Proyecto de Generación de Conocimiento 2025 by the Spanish Ministry of Science, Innovation and Universities

Introduction to the vacant position:

The Biosensors for Bioengineering Group is looking for an highly motivated PhD candidate to develop their doctoral thesis project on the development of an advanced human 3D skeletal muscle tissue models and high-throughput drug screening platforms for Myotonic Dystrophy type 2 (DM2). The PhD project will be conducted in the framework of the project entitled: Myotonic dystrophy type 2 Drug Repurposing using Advanced in vitro human models (MY2DREAM).

This fellowship is associated with the research project Generación de Conocimiento, funded by the Spanish Ministry of Science, Innovation and Universities.

Main tasks and responsibilities:
- Generation and characterization of engineered 3D skeletal muscle tissues derived from DM2 patient and healthy-donor myoblasts, including functional, structural and molecular profiling.
- Implementation and optimization of a high-throughput screening (HTS)



platform based on high-content confocal imaging and multiparametric analysis to screen a a drug repurposing library.
- Preclinical validation of prioritized repurposed drug candidates in the bioengineered 3D DM2 muscle models.

Requirements for candidates:
- Essential:
- BSc and MSc in biology, biotechnology, biomedical engineering, biomedicine, pharmacy or similar areas
- Candidates should be ready to enter an official doctoral programme in December 2026 (under Spanish Law). By this time, they must have obtained a university degree and a master’s degree; or must hold an official university qualification from a country of the European Higher Education Area with a minimum of 300 ECTS of official university studies, of which at least 60 are at master’s level. Candidates who expect to be awarded with such degrees by October 2026 are eligible to apply.
- Candidates must have a strong commitment to scientific research and an excellent academi

📌 Predoctoral researcher at the Biosensors for Bioengineering Research Group/ (Barcelona)
🏢 Barcelona Institute Of Science And Technology (Bist)
📍 Barcelona