SpliceBio is a biotechnology company developing the next generation of genetic medicines through its proprietary Protein Splicing platform. Our mission is to unlock the potential of gene therapy by enabling the delivery of therapies beyond the size limitations of conventional approaches, with the goal of addressing diseases with significant unmet medical need.

Built on more than 20 years of pioneering research in inteins and protein engineering from the Muir Lab at Princeton University, SpliceBio is headquartered in Barcelona and operates in a highly collaborative, international environment.

The Role As

Scientist, Preclinical Ophthalmology , you will play a key role in supporting and advancing scientific research across our Ophthalmology portfolio.

You will independently design and conduct laboratory experiments, analyse and interpret complex datasets, and contribute to the planning and development of ocular research projects. Working closely with other Scientists, Technicians and cross-functional teams, you will provide technical guidance, share scientific expertise and help ensure high-quality, robust and meaningful research outcomes.

This role is ideal for a scientist who combines strong hands-on experimental capabilities with a

versátil, collaborative and project-oriented mindset , and who is motivated to translate scientific expertise into therapeutic development within a dynamic biotech environment.

Main Responsibilities

Independently design and execute experiments aligned with project objectives.

Optimize and troubleshoot experimental protocols to improve accuracy, efficiency and reproducibility.

Coordinate and collaborate with cross-functional team members to ensure effective experimental workflows.

Apply scientific judgement to adapt experimental approaches as project needs evolve.

2. Data Analysis, Interpretation & Reporting

Perform detailed analysis of experimental data using appropriate analytical and statistical approaches.

Independently interpret results and draw scientifically meaningful conclusions.

Prepare high-quality scientific reports, presentations and summaries for internal and external audiences.





Clearly communicate experimental outcomes and their implications for project development.

Actively contribute to scientific project planning and decision-making.

Combine

hands-on experimental work with project ownership , planning activities and managing assigned deliverables and timelines.

Coordinate effectively with relevant stakeholders and multidisciplinary teams.

Provide technical guidance and mentorship to Technicians and Junior Scientists when required.

4. Scientific Development & Innovation

Stay current with scientific literature, emerging technologies and new methodologies relevant to ophthalmology, neuroscience, gene therapy and related areas.

Apply new scientific knowledge to improve methodologies and support innovation.

Participate actively in scientific discussions, seminars and collaborative problem-solving sessions.

What We're Looking For

PhD, PhD nearing completion, or equivalent relevant experience

in ophthalmology, neuroscience, gene therapy or a related scientific field

At least

4 years of laboratory experience , with demonstrated ability to independently perform experiments and analyse data

Candidates coming from

academic research environments are welcome , particularly those motivated to apply their scientific expertise within a fast-moving biotechnology environment

Hands-on experience with a range of bioanalytical techniques, including but not limited to:

Brightfield and fluorescence microscopy

Molecular biology techniques

Biochemistry techniques

Strong ability to analyse complex datasets and independently derive meaningful scientific insights

Strong problem-solving skills, with the ability to address complex scientific challenges and propose innovative solutions





High attention to detail and commitment to scientific quality and reproducibility

Strong ability to work effectively within a team and foster collaboration across disciplines

A

flexible and industry-oriented mindset , with the ability to adapt scientific approaches, tasks and priorities as projects evolve

Ability to combine

scientific depth with effective project management , managing multiple activities and deliverables in an organised manner

Business proficiency in

English , both written and spoken

Highly Valued Experience Experience in any of the following areas will be considered a strong advantage:

Previous experience in a

biotechnology or pharmaceutical industry environment is highly valued; 2+ years would be an advantage

Experience in

translational research , connecting preclinical findings with clinical relevance and therapeutic development

Extensive experience working with

rodents for experimental purposes , ideally recognised by the Generalitat de Catalunya

Experience in

preclinical ocular gene therapy , particularly:

In-life monitoring techniques such as

electroretinography (ERG)

Optical coherence tomography (OCT)

in rodent models

Experience with

retinal organoids , including:

Differentiation from induced pluripotent stem cells (iPSCs)

Patient-derived retinal organoids

Organoid maintenance and characterisation

Why Join SpliceBio? We offer:

The opportunity to contribute directly to innovative

gene therapy and ophthalmology programs

Exposure to cutting-edge preclinical research and translational science

A collaborative, multidisciplinary and international working environment

The opportunity to work closely with experienced scientists across different areas of therapeutic development

Competitive compensation and benefits

Career development opportunities in one of the most exciting and rapidly evolving areas of biotechnology

The chance to make a tangible impact on the development of therapies for patients with significant unmet medical needs

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📌 Scientist, Preclinical Ophthalmology (Madrid)
🏢 SpliceBio
📍 Madrid