Nucleotide homeostasis and mitochondrial function:
physiological and therapeutic implications VHIR is seeking an
outstanding and highly motivated postdoctoral researcher to apply
for a Marie Sklodowska-Curie Postdoctoral Fellowship and join the
Neuromuscular and Mitochondrial Disorders Research Group. Marie
Skłodowska-Curie Actions – Postdoctoral Fellowships (MSCA-PF) The
Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA-PF) are part
of the Horizon Europe programme and support postdoctoral
researchers in developing an original research and innovation
project through international mobility. The programme aims to
strengthen researchers’ careers through excellent science,
international collaboration and interdisciplinary experience, while
fostering integration in both academic and non-academic
environments. The MSCA-PF call is highly competitive and represents
an excellent opportunity to attract international talent and
support researchers in consolidating their scientific careers
through an ambitious mobility-based fellowship. The 2026 call
closes on 09/09/2026 (17:00 Brussels time). For candidates applying
to a European Postdoctoral Fellowship, the fellowship duration is
from 12 to 24 months . Full eligibility details: MSCA Postdoctoral
Fellowships 2026 Background Mitochondrial DNA (mtDNA)
depletion/deletions syndromes (MDDS) are severe conditions caused
by mutations in nuclear genes involved in mtDNA replication. dNTP
imbalances are often associated to these disorders, either because
the primary gene is involved in dNTP anabolic or catabolic
pathways, or because the mtDNA aberrations secondarily alter dNTP
metabolism. The dNTP homeostasis is a therapeutic target for some
MDDS . For instance, mitochondrial neurogastrointestinal
encephalomyopathy (MNGIE) is caused by the toxic accumulation of
thymidine and deoxyuridine, and the treatments of this disorder aim
to clear the overload of these metabolites. Also, the recent
approval of thymidine and deoxycytidine to tr