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Research trainee in the Intracellular Compartmentation lab
Research trainee in the Intracellular Compartmentation lab
The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a adaptable and efficient administration and by high-end and innovative technologies.
The Malhotra lab is looking to hire a research trainee. The candidate is expected to contribute to the study of the process of unconventional protein secretion in yeast and/or mammalian tissue culture cells. The candidate should have a background in cell biology, with a special interest in trafficking and quality control of proteins for secretion outside of the cell.
About the lab
The Intracellular compartmentation lab studies different aspects of protein secretion.



Protein secretion is an old problem of fundamental interest in cell biology. While over the last decades a lot of progress has been made in understanding protein secretion, a number of questions remain unsolved. The lab aims to understand different aspects of this. On the one hand they focus on the transport and secretion of large, complex cargoes (like collagens and mucins) that do not fit the conventional secretory pathway. On the other hand, they study the process whereby cytoplasmic, signal sequence lacking proteins are secreted from cells upon certain stimuli (known as unconventional protein secretion). Research performed in the lab has implicated a yeast protein called Grh1 to be central in the unconventional secretion of a number of cytoplasmic proteins. However, the exact mechanism by which cargoes are selected and how Grh1 contributes to their secretion remains unclear to date. The lab is currently investigating th

📌 Research trainee in the Intracellular Compartmentation lab (Barcelona)
🏢 Centre For Genomic Regulation
📍 Barcelona