You are here:Home > Research trainee in the Intracellular Compartmentation labResearch trainee in the Intracellular Compartmentation labResearch trainee in the Intracellular Compartmentation labThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a versátil and efficient administration and by high-end and innovative technologies.The Malhotra lab is looking to hire a research trainee. The candidate is expected to contribute to the study of the process of unconventional protein secretion in yeast and/or mammalian tissue culture cells. The candidate should have a background in cell biology, with a special interest in trafficking and quality control of proteins for secretion outside of the cell.About the labThe Intracellular compartmentation lab studies different aspects of protein secretion. Protein secretion is an old problem of fundamental interest in cell biology. While over the last decades a lot of progress has been made in understanding protein secretion, a number of questions remain unsolved. The lab aims to understand different aspects of this. On the one hand they focus on the transport and secretion of large, complex cargoes (like collagens and mucins) that do not fit the conventional secretory pathway. On the other hand, they study the process whereby cytoplasmic, signal sequence lacking proteins are secreted from cells upon certain stimuli (known as unconventional protein secretion). Research performed in the lab has implicated a yeast protein called Grh1 to be central in the unconventional secretion of a number of cytoplasmic proteins. However, the exact mechanism by which cargoes are selected and how Grh1 contributes to their secretion remains unclear to date. The lab is currently investigating the role of mammalian Grh1 (GRASP)



proteins in the secretion of selected cytoplasmic cargoes, such as ACBP.Whom would we like to hire?Professional experienceMust HaveYou have experience in cell biology, molecular biology, biochemistryYou are eager to learn and work in a collaborative research environmentDesirable but no required / Nice to haveYou have imaging skills (epifluorescence as well as confocal microscopy, fixed cells as well as life cell imaging)You have experience in protein analysis techniquesYou have knowledge of DNA & RNA techniquesYou have experience in gene editing techniques in tissue culture cellsYou have advanced software skills (Adobe Acrobat, ImageJ)Education and trainingYou hold a Master’s degree in biology, biochemistry, biomedical sciences, biotechnology, or a related fieldLanguagesYou are proficient in EnglishTechnical skillsYou have experience of mammalian cell culture techniquesYou have knowledge of working with yeast as a model systemYou have knowledge with standard cellular, molecular biology and microbiologicaltechniquesYou have knowledge of protein analysis techniquesYou have advanced MS Office software skillsCompetencesExcellent organisational skillsWorks well in a team, but is also capable of working in an independent mannerThe Offer – Working ConditionsEstimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.Contract funded by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No )
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📌 Research trainee in the Intracellular Compartmentation lab (Barcelona)
🏢 Centre For Genomic Regulation
📍 Barcelona