The Trial Safety Review Center (TRISARC) is a department in the Research and Development function of AstraZeneca. The primary remit of the TRISARC is to review large amounts of clinical (mainly safety) data flowing through the clinical trial environment in order to ensure patient data is complete and medically accurate thus allowing study physicians and/or clinical(project) scientists to interpret medical/safety data efficiently. The Senior Scientist I, Clinical Trial Safety works closely with the core and extended study teams at every stage of the clinical trial. During study set up he/she ensures well-defined standards are outlined and appropriate eCRF modules and Safety Monitoring agreements are in place. During the recruitment and maintenance phases of the clinical trial, he/she uses the Center’s data review tool to review and query important clinical/safety data within the scope agreed with Medical team and documented accordingly. The Senior Scientist I also prepares and facilitates meeting related to review of Study Level safety data.



He/she supports study teams via writing patient narratives for qualifying events, if applicable.
Typical Accountabilities
• Ensure consistent processes and efficient review of critical clinical/safety data • Review of patient-level clinical/safety data on an ongoing basis to ensure medical accuracy and completeness, coding consistency and generate applicable queries as needed to obtain information for appropriate medical assessment and case closure
• Prepare aggregated data visualization and facilitate meetings related to review of safety data on study level
• Contribute to study start-up activities according to the applicable process/procedures (ex. input to the applicable documents, tools set up)
• Serve as a member of the Extended Study Team and report on TRISARC deliverables
• Work with the study physicians and/or clinical/project scientists to support standardized high-level data review and medical evaluation
• Escalate urge

📌 Senior Scientist, Clinical Trial Safety (Barcelona)
🏢 AstraZeneca
📍 Barcelona