Overview The Höpfler lab at the Institute for Genomic Regulation (CRG) is offering a postdoctoral position focused on RNA biology and gene regulation. The role involves leading a project to develop sequencing methods that identify messenger RNA (mRNA) decay substrates and to decipher the mechanisms of degradation.

Responsibilities

Develop sequencing approaches to identify peptide-mediated mRNA decay (PMD) substrates

Perform bioinformatic data analysis and visualization of sequencing datasets

Identify and mechanistically characterize PMD candidate substrates

Present data at international conferences and prepare manuscripts

Lead and manage international collaborations

Actively participate in lab meetings and contribute to a culture of technical excellence and scientific curiosity

Qualifications We are particularly interested in candidates with a hybrid wet‑lab and bioinformatics background who have a track record in RNA biology or gene regulation.

Must Have

Bioinformatics experience in the analysis of (RNA) sequencing data

Experience with common laboratory techniques in cell and molecular biology

PhD degree (or expected to complete the degree before starting) in cell/molecular biology, bioinformatics, or a related field

Strong publication record commensurate with career stage

Ability to pursue research projects independently

Desirable

Experience with massively parallel reporter assays (MPRAs)





Experience exploring mRNA turnover on a transcriptome‑wide scale

Background in RNA biology, translational control, or related areas

Languages

Fluency in written and spoken English

Computer Skills

Proficiency with data analysis software (R, Python)

Experience using high‑performance computing clusters

Advanced MS Office experience

Competences

Curiosity and critical thinking

Rigor, organization, and autonomy

Strong analytical, interpersonal, and communication skills

Offer – Working Conditions

Contract duration: Technical and scientific activities contract (estimated duration 2 years)

Estimated annual gross salary: Salary will be commensurate with qualifications and consistent with our pay scales

Target start date: from October 2026 (versátil)

EEO Statement We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconciling work and family life of its employees and offers extended vacation periods and the possibility to benefit from flexible working hours.

Application Deadline The position will remain open until it is covered.

Contact Markus Höpfler [email protected] Additional information can be found on the lab website: https://www.crg.eu/en/programmes-groups/hopfler-lab

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📌 Postdoc in the Dynamics of Protein Synthesis and RNA Decay Lab (Madrid)
🏢 Somma
📍 Madrid