Overview
The Höpfler lab at the Institute for Genomic Regulation (CRG) is offering a postdoctoral position focused on RNA biology and gene regulation. The role involves leading a project to develop sequencing methods that identify messenger RNA (mRNA) decay substrates and to decipher the mechanisms of degradation.
Responsibilities
- Develop sequencing approaches to identify peptide-mediated mRNA decay (PMD) substrates
- Perform bioinformatic data analysis and visualization of sequencing datasets
- Identify and mechanistically characterize PMD candidate substrates
- Present data at international conferences and prepare manuscripts
- Lead and manage international collaborations
- Actively participate in lab meetings and contribute to a culture of technical excellence and scientific curiosity

Qualifications
We are particularly interested in candidates with a hybrid wet‑lab and bioinformatics background who have a track record in RNA biology or gene regulation.
Must Have
- Bioinformatics experience in the analysis of (RNA) sequencing data




- Experience with common laboratory techniques in cell and molecular biology
- PhD degree (or expected to complete the degree before starting) in cell/molecular biology, bioinformatics, or a related field
- Strong publication record commensurate with career stage
- Ability to pursue research projects independently

Desirable
- Experience with massively parallel reporter assays (MPRAs)
- Experience exploring mRNA turnover on a transcriptome‑wide scale
- Background in RNA biology, translational control, or related areas

Languages
- Fluency in written and spoken English

Computer Skills
- Proficiency with data analysis software (R, Python)
- Experience using high‑performance computing clusters
- Advanced MS Office experience

Competences
- Curiosity and critical thinking
- Rigor, organization, and autonomy
- Strong analytical, interpersonal, and communication skills

Offer – Working Conditions
- Contract duration: Technical and scientif

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