Research Assistant in Brain Vascular Epigenomics - UK Dementia Research Institute
Job Type: Full-Time.
Starting Salary: 43863 plus benefits
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About the role
Launched in 2017, the UK Dementia Research Institute stands as a beacon of scientific innovation, representing an unprecedented 300 million investment in dementia research - the largest of its kind in UK history. The purpose of the UK DRI is to transform the outlook for people living with or at risk of neurodegenerative conditions through research.
We are inviting applications for a Research Assistant in computational brain vascular epigenomics, funded by the Uren Foundation, to join the laboratory of Dr Alexi Nott ( ) in the UK DRI at Imperial College London .
Vascular dysfunction is one of the earliest pathological features of dementia, preceding clinical onset and representing a critical but underexplored window for therapeutic intervention.



Our recent work has demonstrated that the brain neurovascular unit is a key driver of genetic risk for small vessel disease, and that epigenomic profiling of vascular cell types can be used to prioritise repurposable drug targets for dementia (Ziegler et al., Neuron , 2026). The successful candidate will contribute to a translational research project investigating cell-type-specific gene regulatory mechanisms underlying small vessel disease, with the aim of identifying targets of vascular dysfunction relevant to dementia. This work carries direct translational potential, with the opportunity to contribute to the prioritisation of both repurposable and novel therapeutic candidates underpinned by human epigenetic and genetic evidence.
This is an excellent opportunity for a motivated individual with an interest in computational biology to gain experience at the forefront of dementia research. The Nott group is multidisciplinary, and the post holder will work closely with both

📌 Research Assistant in Brain Vascular Epigenomics (Soho)
🏢 Imperial College London
📍 Soho