The idóneo candidate will have strong background in pharmacokinetics and translational modeling. You will participate in implementing innovative and quantitative approaches to advance clinical drug development. Developing, qualifying, and applying mechanistic PBPK models using in vitro, preclinical, clinical, and literature data to support clinical development decisions across therapy areas. In addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP) as per your experience, interests, and expertise dictate.
Typical Accountabilities
Utilize physiologically-based pharmacokinetic (PBPK) and translational modeling tools to enable clinical PK projections for drug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questions
Collaborate with Drug Metabolism and Pharmacokinetic (DMPK) Scientists and Clinical Pharmacology scientists to generate these mechanistic models
Develop fit-for-purpose, qualified PBPK models suitable for internal decision-making and regulatory use,



including support for submission documentation and health authority interactions. Communicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions
Keep up to date with emerging literature, modeling science, and regulatory expectations
Education, Qualifications, Skills and Experience
Essential
PhD degree preferred or equivalent (M.Sc./Pharm.D.)
Experience using PBPK platforms such as Simcyp, GastroPlus, or PK-Sim, together with scripting in R and/or Python for data analysis, visualization, and workflow automation.
Familiarity with AI-enabled scientific workflows, such as literature mining, coding assistance, or document summarization in compliant research environments
Demonstrated broad PBPK expertise and experience exemplified by 1-4 Years of drug development experience, with emphasis on PB

📌 Senior Clinical PBPK Modeling Scientist (Barcelona)
🏢 AstraZeneca
📍 Barcelona