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Endometrial cancer (EC) is the fourth most common cancer in women, and its incidence is increasing. Despite the importance of early diagnosis for patient survival, there is no accurate and non?invasive strategy for early triage or screening of EC. Diagnosis relies on imaging and invasive biopsies, affecting more than 35 M women presenting symptoms – 86% postmenopausal and 14% premenopausal – and patients with hereditary risk – Lynch Syndrome – who have annual surveillance. Only 10% of those will have EC.
Objective
This project builds on our previous projects, and aims to advance the development of a non?invasive triage test based on protein biomarkers in cervical fluids for the accurate detection of atypical endometrial hyperplasia (AEH) and EC across high?risk populations. We will advance the development, preanalytical and analytical validation of the test using the recently developed key reagents,
and assess its performance in symptomatic pre? and postmenopausal women prior and after imaging techniques, and Lynch Syndrome carriers. In parallel, we will investigate the proteomic landscape of EC progression using a transgenic mouse model, and cervical fluids from AEH patients, to elucidate tumour progression mechanisms and AEH biomarkers, with the ultimate goal to advance our triage test for EC prevention. This project is expected to transform EC diagnosis, improving patient care, quality of life, EC survival, and healthcare efficiency.
Our Group
The Group of Biomedical Research in Gynaecology (Gine Lab), integrated into the Vall d'Hebron Research Institute (VHIR), is a consolidated, multidisciplinary core consisting of 37 professionals who operate under a "two?way translational research" philosophy: from the patient to the laboratory and back to the clinic. The group is co?directed by Dr. Antonio Gil?Moreno, who le
📌 Vhir-Msca-Pf-2026.009_Postdoctoral Fellowship (Barcelona)
🏢 Fundació TIC Salut i Social
📍 Barcelona
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