Organisation/Company IDIBELL Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 5 Aug 2026 - 12:30 (Europe/Madrid) Country Spain Type of Contract To be defined Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The Laboratory of Cancer Metabolism is looking for a highly motivated postdoctoral candidate willing to participate to the next call of Marie Curie Postdoctoral Fellowship and other mobility fellowship programs (EMBO LTF, Human Frontiers HFSP etc.).

The group focuses on understanding how the process of oncogenic transformation reprograms the translatome, particularly (1) how metabolic changes alter the repertoire of translated mRNAs and (2)



how cancer cells can exploit such translational networks to survive and overcome standard chemotherapeutic regimens in colorectal cancer and other MYC-driven tumors.

We have identified a specialized subset of 40S ribosomes, which in a complex with the RNA binding protein LARP1, bind and preserve a discrete population of mRNAs, termed 5’TOPs, which not only include Ribosomal Proteins (RPs) and translational factors, but also a new set of anabolic mRNAs (Gentilella et al., Molecular Cell 17), which can be translationally switched ON and OFF depending on the cellular metabolic state (Fuentes et al, Science Advances 21; Morcelle et al, Cancer Res 19, Fuentes et al., NAR Cancer 2024). This mechanism plays a major role in MYC-driven oncogenesis, preparing the anabolic potential of transformed cellsin a poised state and connecting it with the metabolic sensing pathway governed by mTOR (Fuentes et al., PNAS 2026).

The long term goal of the lab is to understand by a multi-disciplinary approach cellular adapt

📌 Postdoctoral candidate in Cancer Metabolism (MSCA applicant) (España)
🏢 Idibell
📍 España