pbTakeTalent /bjoins bPharmaMar i /bn the search for a bClinical Pharmacology Scientist /bto support the development of innovative oncology therapies through cutting-edge bclinical pharmacology /band bmodel-informed drug development strategies /b. /ppbr/ppAt bPharmaMar /b, they are committed to advancing science and transforming patient outcomes through innovative oncology research. The Clinical Pharmacology team plays a critical role in early clinical development, generating the pharmacokinetic, pharmacodynamic and translational insights needed to optimize drug development and support regulatory decision-making. /ppbr/ppbWhat will you do? /b /ppbr/pp• Support the implementation of Clinical Pharmacology and Early Clinical Development plans with scientific rigor and a high level of autonomy. /pp• Provide guidance and scientific mentorship to Clinical Pharmacology Scientists and Associate Scientists within the team. /pp• Coordinate and oversee bioanalytical activities, including sample shipment tracking, vendor management, review of validation plans, budgets and work orders. /pp• Perform pharmacokinetic analyses, including Non-Compartmental Analysis (NCA), Population Pharmacokinetic (PopPK) analysis and Physiologically Based Pharmacokinetic (PBPK) modeling. /pp• Conduct pharmacodynamic and PK/PD analyses to assess treatment efficacy, dose-limiting toxicities and exposure-response relationships. /pp• Support first-in-human (FIH) studies, including ECG/Holter monitoring activities and c-QT/t-QT analyses. /pp• Contribute to Model-Informed Drug Development (MIDD) initiatives through pharmacometric analyses, simulations and interpretation of results.



/pp• Develop and maintain high-quality analytical workflows and databases following Good Coding Practices. /pp• Contribute to Clinical Pharmacology sections of study protocols, development plans, scientific publications and technical reports. /pp• Provide scientific support to Regulatory Affairs activities and interactions with agencies such as the EMA and FDA. /pp• Collaborate closely with cross-functional teams including Medical Oncology, Biostatistics, Data Management and other key stakeholders. /pp• Participate in departmental initiatives that contribute to the overall success of Early Clinical Development programs. /ppbr/ppbPosition requirements /b /ppbr/pp• Bachelor’s degree in bPharmacy, Medicine, Biology, Biotechnology /b or a related scientific discipline. /pp• Master’s degree and PhD in bPharmacology /b, Immunology, Computational Biology, Bioinformatics, Biostatistics or a related field. /pp• Fluent English, both written and spoken. /pp• More than 3 years of experience in clinical research, preferably within pharmacology, immunology or translational medicine. /pp• Experience authoring scientific publications and technical reports. /pp• Proven expertise in pharmacometric modeling tools such as bNONMEM, Monolix,



PK-Sim or similar platforms. /b /pp• Strong programming skills in R and SAS for data analysis and process automation. /pp• Knowledge of additional programming languages such as Python and Bash. /pp• Experience in bioanalysis and biomarker evaluation. /pp• Solid understanding of statistical methodologies, including descriptive, univariate and multivariate analyses. /pp• Experience withb Next-Generation Sequencing /b(NGS), pharmacogenetics, genotyping analyses and bioinformatics pipelines. /pp• Excellent communication skills and the ability to work independently while contributing effectively within multidisciplinary teams. /ppbr/ppbWhat do we offer? /b /ppbr/pp• Competitive annual salary and performance-based bonus. /pp• Comprehensive benefits package, including private health insurance, employee share plan, company canteen, continuous training and development opportunities, among others. /pp• Adaptable start time (7:30h to 9:30h) and intensive working hours on Fridays. /pp• Hybrid working model available after successfully completing the six-month probation period, combining on-site collaboration with remote work flexibility. /pp• The opportunity to contribute to groundbreaking oncology research in an innovative and science-driven environment. /pp• A strong commitment to diversity, equal opportunities and an inclusive work environment where all talent is valued and respected. /ppbr/ppbIf you are passionate about clinical pharmacology, translational science and innovative drug development, we would love to hear from you. /b /p

📌 Clinical Pharmacology Principal Scientist (Madrid)
🏢 BUSINESS SOLUTIONS by TakeTalent
📍 Madrid