ph3The Institute /h3 pbThe Institute /b /p pThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end innovative technologies. /p h3The role /h3 pThe Höpfler lab is looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation with a strong interest in driving development of sequencing methods to identify mRNA decay substrates and decipher degradation mechanisms. /p pThe successful candidate will join the Dynamics of Protein Synthesis and RNA Decay Group. Their work will address an exciting question in gene regulation: how cells dynamically control the stability of messenger RNAs by selective degradation during protein synthesis by the ribosome. The lab studies this problem in the context of both fundamental molecular mechanisms and disease‑related regulation. /p pThe position will be a chance to join a young, ambitious and curiosity‑driven lab at the CRG, one of Europe’s prime institutes for molecular life sciences, surrounded by the dynamic Barcelona research environment. The project is embedded in the ERC‑funded DECODE‑PMD project to better understand peptide‑mediated mRNA decay (PMD). /p h3Key responsibilities include: /h3 ul liDevelopment of sequencing approaches to identify PMD substrates /li liBioinformatic data analysis and visualization /li liIdentification and mechanistic characterization of PMD candidate substrates /li liPresentation of data at international conferences and manuscript preparation /li liLeading and managing international collaborations /li liActive participation in lab meetings and contribution to a culture of technical excellence and scientific curiosity /li /ul h3Whom would we like to hire? /h3 pWe are particularly interested in candidates with a hybrid wet lab + bioinformatics background with a track record in RNA biology or gene regulation, but we will consider applications with related expertise. Experience with sequencing approaches to study RNA turnover or with massively parallel reporter assays (MPRAs) will be beneficial. /p h3Must Have /h3 ul liBioinformatics experience in the analysis of (RNA) sequencing data /li liExperience with common lab techniques in cell molecular biology /li liThe candidate must hold a PhD degree, preferably in cell/molecular biology or bioinformatics, or related fields (or expect to finish the degree before starting) /li liA strong publication record commensurate with career stage /li liAbility to pursue research projects independently /li /ul h3Desirable but not required / Nice to have /h3 ul liExperience with massively parallel reporter assays of any kind /li liExperience with studying mRNA turnover on a transcriptome‑wide scale /li /ul h3Languages /h3 ul liFluency in written and spoken English /li /ul h3Computer skills /h3 ul liSkilled with data analyses software (R/Python) /li liExperience with using high performance computing clusters /li liAdvanced MS Office experience /li /ul h3Competences /h3 ul liCuriosity and critical thinking /li liRigor, organization and autonomy /li liStrong analytical, interpersonal, and communication skills /li /ul h3The Offer – Working Conditions /h3 ul liContract duration: Technical and scientific activities contract (estimated duration 2 years) /li liEstimated annual gross salary:



Salary will be commensurate with qualifications and consistent with our pay scales /li /ul h3Target start date /h3 pFrom October 2026 (adaptable). We provide a highly stimulating environment with state‑of‑the‑art infrastructures, and unique professional career development opportunities. /p h3EEO Statement /h3 pWe offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity. /p h3Work‑Life Balance /h3 pThe CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours. /p h3Application Procedure /h3 pAll applications must include: /p ol liA motivation letter addressed to Dr. Markus Höpfler. /li liA complete CV including contact details and publications. /li liContact details of two to three referees. /li /ol h3Selection Process /h3 ul liPre‑selection: The pre‑selection process will be based on qualifications and expertise reflected on the candidates’ CVs. It will be merit‑based. /li liInterview: Preselected candidates will be interviewed by the hiring manager of the position and a selection panel if required. /li liOffer Letter: Once the successful candidate is identified the people department will send a job offer, specifying the start day, salary, working conditions, among other important details. /li /ul h3Deadline /h3 pPlease submit your application before 31/05/2025. /p h3Contact /h3 pMarkus Höpfler – /p /p #J-18808-Ljbffr

📌 Postdoc in the Dynamics of Protein Synthesis and RNA Decay Lab (Barcelona)
🏢 Centre For Genomic Regulation
📍 Barcelona