pOrganisation/Company Universitat Internacional de Catalunya Department Biomedicine Research Field Neurosciences » Other Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 31 Oct 2026 - 23:59 (Europe/Madrid) Country Spain Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Sep 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No /ppemCatalunya (UIC Barcelona) is looking for a highly motivated predoctoral student to join a research project /em /ppemfocused on the cellular and metabolic functions of Carnitine Palmitoyltransferase 1C (CPT1C). /em /ppemCPT1C is an atypical member of the CPT1 protein family. Unlike CPT1A and CPT1B, CPT1C does not display /em /ppemclassical carnitine palmitoyltransferase enzymatic activity. Instead, CPT1C is mainly localized at the /em /ppemendoplasmic reticulum and is highly expressed in neurons, where it is thought to act as a metabolic sensor and /em /ppemregulator of cellular adaptation to nutritional and energetic stress. CPT1C has also been found to be /em /ppemoverexpressed in several tumour types, including glioblastoma, suggesting that this protein may contribute to /em /ppemmetabolic plasticity in both neuronal and cancer contexts. /em /ppemThe proposed PhD project will investigate the role of CPT1C from two complementary perspectives. First, the /em /ppemproject will study the contribution of CPT1C to the regulation of glucose metabolism and the Warburg /em /ppemphenotype in glioblastoma cells. Second,



the project will explore the role of CPT1C in the nervous system /em /ppemthrough the identification and validation of novel CPT1C-interacting proteins in a neuronal context. /em /ppemThe work will include the use of glioblastoma cell models, neuronal or brain-derived samples, CPT1C knockout /em /ppemand rescue strategies, protein interaction studies, metabolic assays and molecular biology techniques. /em /ppemExperimental approaches may include cell culture, CRISPR-based models, transient or stable transfection, RTqPCR, /em /ppemWestern blot, co-immunoprecipitation, proximity ligation assays, immunofluorescence/confocal /em /ppemmicroscopy, subcellular fractionation, glucose and lactate measurements, proliferation and viability assays, /em /ppemand methods related. /em /ppemThis project is especially suited for candidates interested in metabolism, protein-protein interactions, cancer /em /ppemcell biology, neuronal biology and molecular mechanisms of cellular adaptation to stress. The PhD student will /em /ppembe trained in a multidisciplinary environment combining biochemistry, molecular biology, cell biology, /em /ppemmetabolism and neurobiology. /em /ppemThe PhD student will be supervised by researchers from the Neurolipid Group at UIC Barcelona. The candidate /em /ppemwill be encouraged to participate in national and international conferences, present their work, collaborate with /em /ppemother research groups and attend specialized courses to complement their scientific training. The PhD student /em /ppemwill also be required to contribute to teaching activities at UIC Barcelona, up to a maximum of 60 hours per /em /ppemacademic year, in subjects related to Health Sciences degrees. /em /p #J-18808-Ljbffr

📌 PREDOCTORAL POSITION IN BIOCHEMISTRY, METABOLISM AND CELL BIOLOGY (España)
🏢 Universitat Internacional de Catalunya
📍 España