Original Articles Vol. 35 No. 3 (2026): Turkish Journal of Nephrology DOI: 10.5152/turkjnephrol.2026.251080 Article Sidebar Full Text PDF Published: Jul 6, 2026 Keywords Kidney biopsy, idney parenchymal disease, pathology How to Cite Gibyeli Genek, D., Terzioğlu Yazıcı, G. C., Bacaksızlar Sarı, F., Örgün Sönmez, M. G., Alp, A., & Huddam, B. (2026).

Clinicopathological

Analysis of Native Kidney Biopsies: Single-Center Experience In Muğla Province.

Turkish

Journal of Nephrology, 35(3), 208–215. https://doi.org/10.5152/turkjnephrol.2026.251080 ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Endnote/Zotero/Mendeley (RIS) BibTeX Main Article Content Dilek Gibyeli Genek Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0001-6104-5577 Gülsüm Ceren Terzioğlu Yazıcı Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0001-9833-9093 Ferda Bacaksızlar Sarı Department of Radiology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-6293-9481 Mürşide Gülay Örgün Sönmez Department of Pathology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-6981-8076 Alper Alp Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-2864-361X Bülent Huddam Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-8412-1584 Clinicopathological Analysis of Native Kidney Biopsies: Single-Center Experience In Muğla Province Main Article Content Dilek Gibyeli Genek Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0001-6104-5577 Gülsüm Ceren Terzioğlu Yazıcı Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0001-9833-9093 Ferda Bacaksızlar Sarı Department of Radiology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-6293-9481 Mürşide Gülay Örgün Sönmez Department of Pathology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-6981-8076 Alper Alp Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-2864-361X Bülent Huddam Division of Nephrology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Türkiye https://orcid.org/0000-0002-8412-1584 Abstract Background: Percutaneous native kidney biopsy remains the gold standard for diagnosing kidney parenchymal diseases, providing essential diagnostic and prognostic information. Despite non-invasive serological markers, biopsy continues to play a key role in clinical nephrology.

Methods:



This retrospective study evaluated 174 adult native kidney biopsies performed between January 2018 and November 2024 at X Training and Research Hospital. Demographic, clinical, laboratory, and histopathological data were analyzed.

Results: The mean age of patients was 49.5 ± 18 years, and males constituted 52.3%. The most frequent comorbidities were hypertension (51.7%) and diabetes mellitus (26.4%). Nephrotic syndrome (29.3%) was the leading biopsy indication, followed by asymptomatic urinary abnormalities (25.3%) and unexplained kidney failure (25.3%).

The most common histopathological diagnosis was focal segmental glomerulosclerosis (17.8%), followed by membranous nephropathy (8.6%) and crescentic/necrotizing glomerulonephritis (7.5%). Focal segmental glomerulosclerosis (FSGS) was more frequent in nephrotic presentations and among elderly patients. Crescentic and rapidly progressive glomerulonephritis were significantly associated with age > 65 years (P < .05).

Immunoglobulin A (IgA) nephropathy incidence was notably low in this cohort, while lupus nephritis occurred exclusively in females. Bleeding complications developed in 13.2% of patients, including 2.8% with major events, with no organ loss or mortality.

Conclusion: This study provides the first regional epidemiological data on native kidney biopsies from province X. The findings demonstrate the increasing frequency and predominance of focal segmental glomerulosclerosis in Türkiye. This pattern, together with an older patient profile, indicates regional variation and underscores the importance of kidney biopsy in monitoring epidemiological trends of glomerular diseases.

Cite this article as: Gibyeli Genek D, Terzioğlu Yazıcı GC, Bacaksızlar Sarı F, Örgün Sönmez MG, Alp A, Huddam B. Clinicopathological analysis of native kidney biopsies: single-center experience in Muğla province. Turk J Nephrol. 2026;35(3):208-215. We recommend LASS I MAJOR HISTOCOMPATIBILITY ANTIGENS IN PRIMARY BILIARY CIRRHOSIS Ömer ÖZÜTEMİZ, et al., Turkish Journal of Gastroenterology, 1994 ESOPHAGEAL FOREIGN BODIES IN CHILDREN AND ADULTS.

Safak

Dagli, et al., Turkish Journal of Gastroenterology, 1994 CELIAC DISEASE IN CHILDHOOD EVALUATION OF 13 PATIENTS B. Altuntas, et al., Turkish Journal of Gastroenterology, 1994 THE PREVALENCE OF HELICOBACTER PYLORI IN PATTENTS WITH UPPER GASTROINTESTINAL COMPLAINTS Ali ÖZDEN, et al., Turkish Journal of Gastroenterology, 1992 BLOOD CA19-9 LEVELS, ENDOSCOPIC APPEARANCE, HISTOPATHOLOGIC EVALUATION OF BIOPSIES FROM EDGE AND AROUND MUCOSA IN GASTRIC ULCERS B. Kara, et al., Turkish Journal of Gastroenterology, 1993 Granulomas in bone marrow biopsies: clinicopathological significance and new perspectives Umberto Maccio, J Clin Pathol,



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Shi Jin, J Clin Pathol, 2024 Powered by Do not sell my personal information Article Details This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract Background: Percutaneous native kidney biopsy remains the gold standard for diagnosing kidney parenchymal diseases, providing essential diagnostic and prognostic information. Despite non-invasive serological markers, biopsy continues to play a key role in clinical nephrology.

Methods: This retrospective study evaluated 174 adult native kidney biopsies performed between January 2018 and November 2024 at X Training and Research Hospital. Demographic, clinical, laboratory, and histopathological data were analyzed.

Results: The mean age of patients was 49.5 ± 18 years, and males constituted 52.3%. The most frequent comorbidities were hypertension (51.7%) and diabetes mellitus (26.4%). Nephrotic syndrome (29.3%) was the leading biopsy indication, followed by asymptomatic urinary abnormalities (25.3%) and unexplained kidney failure (25.3%).

The most common histopathological diagnosis was focal segmental glomerulosclerosis (17.8%), followed by membranous nephropathy (8.6%) and crescentic/necrotizing glomerulonephritis (7.5%). Focal segmental glomerulosclerosis (FSGS) was more frequent in nephrotic presentations and among elderly patients. Crescentic and rapidly progressive glomerulonephritis were significantly associated with age > 65 years (P < .05).

Immunoglobulin A (IgA) nephropathy incidence was notably low in this cohort, while lupus nephritis occurred exclusively in females. Bleeding complications developed in 13.2% of patients, including 2.8% with major events, with no organ loss or mortality.

Conclusion: This study provides the first regional epidemiological data on native kidney biopsies from province X. The findings demonstrate the increasing frequency and predominance of focal segmental glomerulosclerosis in Türkiye. This pattern, together with an older patient profile, indicates regional variation and underscores the importance of kidney biopsy in monitoring epidemiological trends of glomerular diseases.

Cite this article as: Gibyeli Genek D, Terzioğlu Yazıcı GC, Bacaksızlar Sarı F, Örgün Sönmez MG, Alp A, Huddam B. Clinicopathological analysis of native kidney biopsies: single-center experience in Muğla province. Turk J Nephrol. 2026;35(3):208-215.

📌 Clinicopathological Analysis of Native Kidney Biopsies: Single-Center Experience In Muğla Province (Alp)
🏢 Turkish Journal of Nephrology
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