We're looking for a Vice President of Clinical Development to lead the clinical and medical strategy across our drug development pipeline. You'll drive Clinical Development Plans, oversee trial design and execution, and ensure everything we do meets GCP and regulatory standards. This is a senior leadership role with direct visibility to the Executive Team and Board, and regular interaction with regulators, investigators, and partners.

What You'll Do Clinical Strategy & Leadership

Own the clinical development strategy across our portfolio, aligned with corporate goals

Lead and evolve Clinical Development Plans across programs and indications

Guide pipeline progression through all stages of development

Mentor Senior Directors and Clinical Leads, ensuring consistent scientific and medical decision‑making

Program Oversight

Provide strategic oversight of trial execution, working closely with Clinical Operations

Keep programs on track for timelines, quality, and budget

Help guide CRO performance and vendor strategy

Anticipate risks and steer mitigation at the program and portfolio level

Data & Safety

Lead interpretation of efficacy and safety data to inform program decisions

Oversee safety strategy and governance, including escalation and benefit‑risk assessments

Contribute to Data Monitoring Committees and internal safety reviews

Drive data‑based recommendations on program continuation, modification, or termination

Regulatory & Documentation

Provide clinical leadership on regulatory strategy alongside Regulatory Affairs

Review key regulatory filings (INDs, CTAs/IMPDs, NDAs, MAAs, Annual Reports)

Represent Clinical Development in interactions with health authorities (FDA, EMA, and others)

Serve as a senior clinical voice with investigators, KOLs, partners, and collaborators





Build relationships with academic centers and clinical experts in relevant therapy areas

Partner with Research, Preclinical, Biometrics, CMC, Medical Affairs, and Business Development

Support due diligence, fundraising, and partnering discussions

Compliance & Communication

Ensure all clinical activities meet GCP, SOPs, and regulatory standards

Communicate clinical strategy and progress clearly to Executive Team and Board

Represent the company at investigator meetings, advisory boards, and scientific forums

Champion scientific rigor and patient‑centered decision‑making

What You Bring

MD strongly preferred, with 7+ years in clinical development in pharma/biotech (or 10+ years without an MD)

Senior leadership experience running clinical development programs in a clinical‑stage biotech or similarly advanced environment A track record of setting and executing clinical strategy at the program and portfolio level

Strong grasp of general drug development and regulatory frameworks (FDA, EMA), including leading Health Authority interactions

Experience interpreting complex clinical data to guide major development and investment decisions

Background in ophthalmology; experience in gene therapy, rare disease, or other advanced therapeutic modalities is a strong plus

Experience in a similarly sized biotech is a plus

Proven ability to lead cross‑functional teams spanning Clinical Operations, Regulatory Affairs, Biometrics, and Translational Medicine

Experience managing and developing senior clinical leaders

Strong strategic and problem‑solving skills in a fast‑paced environment

Excellent communication skills, comfortable presenting to Executive Leadership, Boards, and external stakeholders

High ethical standards and a commitment to patient safety

Full professional proficiency in English

📌 Vice President Clinical Operations - Ophthalmology (Madrid)
🏢 Skills Alliance
📍 Madrid